Endocrine Abstracts

Thyroid hormones (TH) play a pivotal role in embryonal and postnatal development in vertebrates, hence, their secretion is highly regulated. In clinical practice TSH and free T4 (fT4) are commonly used as the most reliable parameters to evaluate the TH status. But they only represent the TH receptor β driven status of the hypothalamic-pituitary-thyroid axis while organ or tissue specific TH availability may be different. This discrepancy originates in the tissue specific ...